The project has fabricated a material, under the form of non-woven mats, on the basis of a naturally originating biopolymer, which meets all conditions required for a dressing that ensures scarless wound-healing. The non-woven mat slowly releases both an antibiotic and an antifungal agent in order to prevent wound infection, while also undergoing degradation as the wound is healing, therefore not requiring removal. The resulted biodegradation products of the material are not only harmless towards the organism it is applied to, but they also aid the healing process.

Representative images of the non-woven mats, their application on full-thickness burns (II-III), and the appearance of the burn after 21 days. 

The results of the project were disseminated as 4 published research articles, 6 participations at international conferences (1 invited lecture, 3 oral communications and 2 posters) and 1 patent request, as follows: 

Research articles

D. Ailincai, S. Cibotaru, A. Anisiei, C.-G. Coman, A.-S. Pasca, I. Rosca, A.-I. Sandu, L. Mititelu-Tartau, L. Marin, Mesoporous chitosan nanofibers loaded with norfloxacin and coated with phenylboronic acid perform as active dressings to accelerate the healing of burn wounds, Carbohydrate Polymers 2023, 318, 121135, doi: 10.1016/j.carbpol.2023.121135.

A. Anisiei, A.-C. Bostanaru, M. Mares, L. Marin, Imination of chitosan nanofibers in heterogeneous system. Synthesis optimization and impact on the fiber morphology, Cellulose Chemistry and Technology, 55(7-8), 2021, 785-793, doi:10.35812/CelluloseChemTechnol.2021.55.65

A. Ansiei, I. Rosca, A.-I, Sandu, A.Bele, X. Cheng, L. Marin, Imination of Microporous Chitosan Fibers—A Route to Biomaterials with “On Demand” Antimicrobial Activity and Biodegradation for Wound Dressings, Pharmaceutics, 14(1), 2022, 117, doi:10.3390/pharmaceutics14010117.

R. Lungu, M.-A. Paun, D. Peptanariu, D. Ailincai, L. Marin, M.-V. Nichita, V.-A. Paun,. V.-P. Paun, Biocompatible Chitosan-Based Hydrogels for Bioabsorbable Wound Dressings, Gels 8(2), 2022, 107, https://doi.org/10.3390/gels8020107.

Patent request

“Chitosan electrospun mats with controlled co-delivery of antibiotic and bioactive principles”, Luminita Marin, Alexandru Anisiei, Ailincai Daniela, Sandu Cibotaru, Bianca Andreica, Irina Rosca, Registration No. CBI : A / 00478 / 08.08.2022

Participation at international conferences

L. Marin, D. Ailincai, M.-M. Iftime, A.-M. Craciun, A. Bejan, A. Anisiei, B.-I. Andreica, Chitosan imination: an opportunity towards biomaterials with broad application spectrum, 7th International Congress on Biomaterials and Biosensors (BIOMATSEN 2022), Muğla, Turkey, 22 - 28 April, 2022 – invited lecture.

L. Marin, D. Ailincai, S. Cibotaru, A. Anisiei, I. Rosca, L. Mititelu-Tartau, Biodegradable chitosan based nanofibers with broad spectrum antimicrobial activity for wound healing applications, EPF European Polymer Federation 2022, Prague, Czech Republic, June 26 - July 1, 2022 -  oral communication.

A. Anisiei, I. Rosca, A.-I. Sandu, A. Bele, L. Marin, Biodegradable imino-chitosan nanofibers as wound dressing materials, ICMPP – open door to the future, scientific communications of young researchers, MacroYouth’2021, 2nd Edition, Iasi, Romania, November 19, 2021 - oral communication

S. Cibotaru, D. Ailincai, A. Anisiei, L. Marin, Bandages based on chitosan nanofibers for burn healing applications, 12th International Conference on Materials Science and Engineering (BraMat 2022), Brasov, Romania, March 9-11, 2022 - oral communication.

R. Lungu, A. Anisiei, I. Rosca, A.-I. Sandu, D. Ailincai, L. Marin, Double-functionalized chitosan nanofibers for wound healing, Progress in Organic and Macromolecular Compounds, 28th Edition, Iasi, Romania, October 7 - 9, 2021 - poster presentation

S. Cibotaru, D. Ailincai, A. Anisiei, L. Marin, Drug delivery systems based on imino-chitosan nanofibers for burn healing applications, EPF European Polymer Federation 2022, Prague, Czech Republic, June 26 - July 1, 2022 - poster.